Jake Wright

Jake Wright

he/him

Postdoctoral Fellow

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A list of all the posts and pages found on the site. For you robots out there, there is an XML version available for digesting as well.

Pages

Posts

Future Blog Post

less than 1 minute read

Published:

This post will show up by default. To disable scheduling of future posts, edit config.yml and set future: false.

Blog Post number 4

less than 1 minute read

Published:

This is a sample blog post. Lorem ipsum I can’t remember the rest of lorem ipsum and don’t have an internet connection right now. Testing testing testing this blog post. Blog posts are cool.

Blog Post number 3

less than 1 minute read

Published:

This is a sample blog post. Lorem ipsum I can’t remember the rest of lorem ipsum and don’t have an internet connection right now. Testing testing testing this blog post. Blog posts are cool.

Blog Post number 2

less than 1 minute read

Published:

This is a sample blog post. Lorem ipsum I can’t remember the rest of lorem ipsum and don’t have an internet connection right now. Testing testing testing this blog post. Blog posts are cool.

Blog Post number 1

less than 1 minute read

Published:

This is a sample blog post. Lorem ipsum I can’t remember the rest of lorem ipsum and don’t have an internet connection right now. Testing testing testing this blog post. Blog posts are cool.

portfolio

publications

Paper Title Number 2

Published in Journal 1, 2010

This paper is about the number 2. The number 3 is left for future work.

Recommended citation: Your Name, You. (2010). "Paper Title Number 2." Journal 1. 1(2).
Paper URL | Paper PDF

Paper Title Number 3

Published in Journal 1, 2015

This paper is about the number 3. The number 4 is left for future work.

Recommended citation: Your Name, You. (2015). "Paper Title Number 3." Journal 1. 1(3).
Paper URL | Paper PDF

Opposing mechanisms mediate morphine-and cocaine-induced generation of silent synapses

Published in Nature Neuroscience, 2016

This to work that demonstrated that cocaine experience triggers synaptogenesis in D1-type MSNs, while morphine triggers synaptic elimination in D2-type MSNs, resulting in the same net shift in the balance of excitation to D1- and D2-type MSNs in the NAc.

Recommended citation: Graziane, NM, Sun, S#, Wright, WJ#, Jang, D, Zheng, L, Huang, YH, Nestler, EJ, Wang, YT, Schlüter, OM, & Dong Y. (2016). "Opposing mechanisms mediate morphine- and cocaine-induced generation of silent synapses." Nature Neuroscience. 19(17).
Paper URL | Paper PDF

A feedforward inhibitory circuit mediated by CB1-expressing fast-spiking interneurons in the nucleus accumbens

Published in Neuropsychopharmacology, 2017

This work characterizes the local inhibitory synaptic transmission arising from fast-spiking interneurons (FSIs) and local axon collaterals from MSNs within the NAc, which provide feedforward and lateral inhibition, respectively.

Recommended citation: Wright, WJ, Schlüter, OM, & Dong, Y. (2017). "A feedforward inhibitory circuit mediated by CB1-expressing fast-spiking interneurons in the nucleus accumbens." Neuropsychopharmacology. 42(5).
Paper URL | Paper PDF

Stress resilience is promoted by a Zfp189-driven transcriptional network in prefrontal cortex

Published in Nature Neuroscience, 2019

This work identified Zfp-189 as a novel transcriptional regulator that confers resiliency to depression in the mPFC.

Recommended citation: a. Lorsch, Z.S.#, Hamiltion, P.J.#, Ramakrishnan, A., Parise, E.M., Salery, M., Wright, W.J., Lepack, A., Mews, P., Issler, O., McKenzie, A., Zhou, X., Parise, L.F., Pirpinias, S.T., Torres, I.O., Kronman, H.G., Montgomery, S., Loh, Y-H.E., Labonte, B., Conkey, A., Symonds, A.E., Neve, R., Turecki, G., Maze, I., Dong, Y., Zhang, B., Shen, L., Bagot, R.C., & Nestler, E.J. (2019) . "Stress resilience is promoted by a Zfp189-driven transcriptional network in prefrontal cortex." Nature Neuroscience. 22(9).
Paper URL | Paper PDF

Silent synapses dictate cocaine memory destabilization and reconsolidation

Published in Nature Neuroscience, 2019

This work demonstrated that the silencing and re-maturation of cocaine-generated synapses underlies the natural destabilization and reconsolidation of cocaine-associated memories following memory reactivation.

Recommended citation: Wright, W.J.#, Graziane, N.M.#, Neumann, P.A., Hamilton, P.J. Cates, H.M., Fuerst, L., Spenceley, A., Mackinnon-Booth, N., Iyer, K., Huang, Y.H., Shaham, Y., Schlüter, O.M., Nestler, E.J., & Dong, Y. (2020). "Silent synapses dictate cocaine memory destabilization and reconsolidation." Nature Neuroscience. 23(1).
Paper URL | Paper PDF

CREB binding at the Zfp189 promoter within medium spiny neuron subtypes differentially regulates behavioral and physiological adaptations over the course of cocaine use

Published in Biological Psychiatry, 2023

these findings point to the CREB-Zfp189 interaction within the NAc Drd2+ neurons as a molecular signature of chronic cocaine use that is causal in counteracting the reinforcing effects of cocaine.

Recommended citation: Teague C.#, Picone J.#, Wright W.J., Browne C., Silva G., Futamura R., Minier-Toribio A., Estill M., Ramakrishnan A., Martinez-Rivera F., Godino A., Parise E., Schmidt, K.H., Pulido, N.V., Lorsch Z., Hyun Kim J., Shen L., Neve R., Dong Y., Nestler E., Hamilton, PJ. (2023) . "CREB Binding at the Zfp189 Promoter Within Medium Spiny Neuron Subtypes Differentially Regulates Behavioral and Physiological Adaptations Over the Course of Cocaine Use." Biological Psychiatry. 6(15).
Paper URL | Paper PDF

Paper Title Number 4

Published in GitHub Journal of Bugs, 2024

This paper is about fixing template issue #693.

Recommended citation: Your Name, You. (2024). "Paper Title Number 3." GitHub Journal of Bugs. 1(3).
Paper URL

Local and global predictors of synapse elimination during motor learning

Published in Science Advances, 2024

These findings represent the first characterization of the functional properties regulating experience-dependent synapses elimination in the adult brain.

Recommended citation: Hedrick, N.G.#, Wright, W.J.#, & Komiyama, T. (2024). "Local and global predictors of synapse elimination during motor learning." Science Advances. 10(11).
Paper URL | Paper PDF

Temporal dynamics of nucleus accumbens neurons in male mice during reward seeking

Published in Nature Communications, 2024

This work characterizes the temporal dynamics of NAc D1R- and D2R-expressing MSNs during natural, self-paced reward seeking behavior

Recommended citation: Schall, T.A.#, Li, K-L.#, Qi, X#, Lee, B.T., Wright, W.J., Alpaugh, E.E., Zhao, R.J., Liu, J., Li, Q., Zeng, B., Wang, L., Huang, Y.H., Schlüter, O.M., Nestler, E.J, Nieh, E.H., & Dong, Y. (2024). "Temporal dynamics of nucleus accumbens neurons in male mice during reward seeking." Nature Communications. 15(1).
Paper URL | Paper PDF

Distinct synaptic plasticity rules operate across dendritic compartments in vivo during learning

Published in Science, 2025

This work identified the synaptic plasticity rules neurons use in vivo during learing, demonstrating individual neurons simultaneously use multiple rules through different dendritic compartments

Recommended citation: Wright, W.J., Hedrick, N.G., Komiyama, T. (2025). "Distinct synaptic plasticity rules operate across dendritic compartments in vivo during learning." Science. 388.
Paper URL

talks

teaching

Teaching experience 1

Undergraduate course, University 1, Department, 2014

This is a description of a teaching experience. You can use markdown like any other post.

Teaching experience 2

Workshop, University 1, Department, 2015

This is a description of a teaching experience. You can use markdown like any other post.